Corpora amylacea in human hippocampal brain tissue are intracellular bodies that exhibit a homogeneous distribution of neo-epitopes
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چکیده
منابع مشابه
Corpora Amylacea in Human Cadaveric Brain Age Related Differences
The present study was designed to investigate the age related deposits of corpora amylacea (CA) in the human cadaveric brain. It is an observational study which was conducted in the Department of Anatomy, University of Health Sciences, Lahore. The duration of the study was two years. Sixty brain specimens (age 19-72 years) from cadavers were collected from the mortuary of the King Edward Medica...
متن کاملNew perspectives on corpora amylacea in the human brain
Corpora amylacea are structures of unknown origin and function that appear with age in human brains and are profuse in selected brain areas in several neurodegenerative conditions. They are constituted of glucose polymers and may contain waste elements derived from different cell types. As we previously found on particular polyglucosan bodies in mouse brain, we report here that corpora amylacea...
متن کاملCorpora Amylacea of Brain Tissue from Neurodegenerative Diseases Are Stained with Specific Antifungal Antibodies
The origin and potential function of corpora amylacea (CA) remains largely unknown. Low numbers of CA are detected in the aging brain of normal individuals but they are abundant in the central nervous system of patients with neurodegenerative diseases. In the present study, we show that CA from patients diagnosed with Alzheimer's disease (AD) contain fungal proteins as detected by immunohistoch...
متن کاملCorpora amylacea in temporal lobe epilepsy associated with hippocampal sclerosis.
UNLABELLED Hippocampal sclerosis (HS) is the commonest pathology in epileptic patients undergoing temporal lobe epilepsy surgery. Beside, there are an increased density of corpora amylacea (CA) founded in 6 to 63% of those cases. OBJECTIVE verify the presence of CA and the clinical correlates of their occurrence in a consecutive series of patients undergoing temporal surgery with diagnosis of...
متن کاملRegular paper Corpora amylacea from multiple sclerosis brain tissue consists of aggregated neuronal cells
In this report, we describe proteomic analysis of corpora amylacea collected by postmortem laser microdissection from multiple sclerosis (MS) brain lesions. Using low level protein loads (about 30 μg), a combination of two-dimensional electrophoresis with matrix-assisted laser desorption/ ionization-time of flight mass spectrometry and database interrogations we identified 24 proteins of suspec...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2019
ISSN: 2045-2322
DOI: 10.1038/s41598-018-38010-7